ANATOMY

Detailed explanation-1: -Cocaine increases the plasma concentrations of catecholamines including epinephrine and norepinephrine by inhibition of peripheral re-uptake and central sympathetic system stimulation. Increased levels of these catecholamines potentiate activation of the beta-1 receptor and thus lead to increased heart rate.

Detailed explanation-2: -Epinephrine and norepinephrine are similar chemicals that act as both neurotransmitters and hormones in the body. Both substances play an important role in the body’s fight or flight response, and their release into the bloodstream causes increases in blood pressure, heart rate, and blood sugar levels.

Detailed explanation-3: -It is well known that epinephrine increases the strength of contraction and the heart rate.

Detailed explanation-4: -Abstract. Norepinephrine (NE) can raise blood pressure and speed up heart rate. However, because its effect of raising heart rate is less than that of reflex reduction of heart rate caused by the increase of blood pressure, NE causes more heart rate decrease in patients.

Detailed explanation-5: -These two hormones work together in stressful situations to increase blood flow throughout your body. Some of the changes that occur are: Increased heart rate.