ANATOMY

Detailed explanation-1: -Agglutination occurs when an insoluble or particle antigen interacts with an antibody. A positive reaction can be detected macroscopically in a short time. However, the antigen-antibody complex may be seen with the naked eye if the complex size is large. Both IgG or IgM could be involved in the agglutination reaction.

Detailed explanation-2: -Clumping (agglutination) of red blood cells is frequently caused by cold agglutinins. Cold agglutinins are IgM antibodies that may arise following viral or Mycoplasma infections, or in the setting of plasma cell or lymphoid neoplasms. Agglutination of red cells can interfere with red blood cell indices.

Detailed explanation-3: -In hematology, red cell agglutination or autoagglutination is a phenomenon in which red blood cells clump together, forming aggregates. It is caused by the surface of the red cells being coated with antibodies.

Detailed explanation-4: -Agglutination is the clumping of particles. The word agglutination comes from the Latin agglutinare (glueing to).

Detailed explanation-5: -The reaction between red cells and corresponding antibodies usually results in clumping-agglutination-of the red cells; therefore, antigens on the surfaces of these red cells are often referred to as agglutinogens.