ANATOMY

Detailed explanation-1: -The endoplasmic reticulum forms a continuous three-dimensional network of tubules, vesicles, and lamellae. Almost 60% of the endoplasmic reticulum has ribosomes attached to its cytoplasmic surface and is known as the RER.

Detailed explanation-2: -Attached, or bound, ribosomes are found on the exterior of an organelle called the endoplasmic reticulum. Because the ribosomes give the organelle a lumpy appearance, the ribosome-containing portion is called the rough ER.

Detailed explanation-3: -The ribosome that is synthesizing the protein is directly attached to the ER membrane. These membrane-bound ribosomes coat the surface of the ER, creating regions termed rough endoplasmic reticulum, or rough ER (Figure 12-36A).

Detailed explanation-4: -The rough endoplasmic reticulum has on it ribosomes, which are small, round organelles whose function it is to make those proteins.

Detailed explanation-5: -The ER is the largest organelle in the cell and is a major site of protein synthesis and transport, protein folding, lipid and steroid synthesis, carbohydrate metabolism and calcium storage [1–7].