ANATOMY

GENERAL ANATOMY

DIGESTIVE SYSTEM

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Pancreatic juice is stimulated by the release of
A
Secretin
B
Cholecystokinin
C
Enterokinase
D
Both (1) and (2)
Explanation: 

Detailed explanation-1: -Pancreatic juice is stimulated to flow in response to increases in the blood concentrations of two gastrointestinal hormones, secretin and cholecystokinin . Both hormones are liberated from the duodenal mucosa in response to different components of the luminal environment.

Detailed explanation-2: -CCK stimulates pancreatic secretion by two possible mechanisms. First, CCK binds CCK-1 receptors on pancreatic acinar cells and stimulates release of enzymes. A second mechanism is indirect whereby CCK binds CCK-1 receptors on capsaicin-sensitive C-type vagal afferent fibers.

Detailed explanation-3: -Trypsinogen: Trypsinogen is an enzyme of the pancreatic juice which is responsible for activating all the other enzymes of that juice once it is activated. So, the correct option is ‘Cholecystokinin’.

Detailed explanation-4: -Pancreaticobiliary Secretion Cholecystokinin (CCK), which is released from the duodenal mucosal enteroendocrine cells after chemical stimulation by food, activates pancreatic enzyme secretion by stimulating vagal afferents.

Detailed explanation-5: -Final answer: Trypsin is secreted by the pancreas.

There is 1 question to complete.