ANATOMY

Detailed explanation-1: -Cushing’s syndrome results from chronic exposure to excessive circulating levels of glucocorticoids. Cushing’s disease is the most common cause of endogenous hypercortisolism.

Detailed explanation-2: -Too much cortisol can cause some of the hallmark signs of Cushing syndrome-a fatty hump between your shoulders, a rounded face, and pink or purple stretch marks on your skin. Cushing syndrome can also result in high blood pressure, bone loss and, on occasion, type 2 diabetes.

Detailed explanation-3: -Addison’s disease happens when your body doesn’t have enough cortisol (and aldosterone), whereas Cushing’s syndrome happens when your body has too much cortisol (hypercortisolism).

Detailed explanation-4: -Cushing’s disease is a serious condition of an excess of the steroid hormone cortisol in the blood level caused by a pituitary tumor secreting adrenocorticotropic hormone (ACTH).

Detailed explanation-5: -What is the difference between Cushing disease and Cushing syndrome? Cushing disease occurs when Cushing syndrome is caused by an ACTH-producing pituitary tumor, whereas Cushing syndrome is the set of symptoms that results when there is a surplus of cortisol in the body.