ANATOMY

Detailed explanation-1: -Also known as dipsogenic diabetes insipidus, this condition can cause production of large amounts of diluted urine from drinking excessive amounts of fluids. Primary polydipsia can be caused by damage to the thirst-regulating mechanism in the hypothalamus.

Detailed explanation-2: -In rare cases, the kidneys do not respond to AVP. This causes a specific form of diabetes insipidus called nephrogenic diabetes insipidus. People feel thirsty as the body tries to compensate for the increased loss of water by increasing the amount of water taken in.

Detailed explanation-3: -In a healthy person, AVP acts as a signal to the nephrons to reabsorb water into the body. In nephrogenic diabetes insipidus, the nephrons in the kidneys are not able to respond to this signal, leading to excessive water loss in large amounts of urine. Your thirst increases to try to balance this loss from the body.

Detailed explanation-4: -Diabetes insipidus is caused by a lack of antidiuretic hormone (ADH), also called vasopressin, which prevents dehydration, or the kidney’s inability to respond to ADH. ADH enables the kidneys to retain water in the body. The hormone is produced in a region of the brain called the hypothalamus.

Detailed explanation-5: -Central diabetes insipidus is due to a deficiency in the production of ADH, often resulting from damage to the pituitary gland.