ANATOMY

Detailed explanation-1: -Aldosterone (ALD) is a hormone your adrenal glands release that helps regulate blood pressure by managing the levels of sodium and potassium in your blood.

Detailed explanation-2: -Aldosterone produces these effects by affecting electrolyte transport in both PC and IC. In PC, aldosterone regulates the expression and activity of epithelial sodium channel (ENaC) leading to increased Na+ reabsorption from the filtrate into the circulation.

Detailed explanation-3: -Aldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone is responsible for regulating sodium homeostasis, thereby helping to control blood volume and blood pressure.

Detailed explanation-4: -Aldosterone is the body’s major hormone involved in volume homeostasis because of its effects on sodium reabsorption in the distal nephron.

Detailed explanation-5: -Aldosterone, the primary mineralocorticoid, is synthesized in the outer zone of the adrenal cortex called the zona glomerulosa (ZG). The production of aldosterone is tightly regulated by angiotensin II (Ang II) and circulating potassium levels.