ANATOMY

Detailed explanation-1: -GH hypersecretion results in gigantism or acromegaly, a condition associated with significant morbidity and mortality, while GH deficiency results in growth retardation in children and the GH deficiency syndrome in adults.

Detailed explanation-2: -Acromegaly is a hormonal disorder that develops when your pituitary gland produces too much growth hormone during adulthood. When you have too much growth hormone, your bones increase in size. In childhood, this leads to increased height and is called gigantism.

Detailed explanation-3: -What are the signs and symptoms of gigantism? Excessive amounts of growth hormone (GH) cause the signs and symptoms of gigantism. Children with gigantism can also develop certain symptoms as their pituitary tumor applies pressure to their nearby brain and nerve tissues.

Detailed explanation-4: -Growth hormone (GH) hypersecretion in the human may be due to a GH-secreting tumor, to a GH-releasing-hormone (GHRH) secreting tumor, to disorders of GH feedback regulatory mechanisms, or to functional disturbance of GH regulation in association with systemic disorders, malnutrition, or psychiatric disease (Table 1).

Detailed explanation-5: -As already mentioned, GH is secreted by the somatotroph cells located primarily in the lateral wings of the anterior pituitary.