ANATOMY

Detailed explanation-1: -Symptoms of Addison’s disease The darkening of the skin in Addison’s disease is sometimes referred to as “bronzing ” and usually develops in the areas of the skin that are exposed to direct sunlight. For the patient, the particular coloring will appear unnatural.

Detailed explanation-2: -Why does Addison’s disease cause changes in skin pigmentation? Hyperpigmentation happens in people with Addison’s disease because the adrenal insufficiency causes changes in hormone levels. These hormones changes means that more melanin is produced and the skin appears more tanned.

Detailed explanation-3: -Addison’s disease is usually the result of a problem with the immune system, which causes it to attack the outer layer of the adrenal gland (the adrenal cortex), disrupting the production of the steroid hormones aldosterone and cortisol.