ANATOMY

Detailed explanation-1: -Synaptic vesicles play the central role in synaptic transmission. They are regarded as key organelles involved in synaptic functions such as uptake, storage and stimulus-dependent release of neurotransmitter.

Detailed explanation-2: -Neurotransmitters are located in a part of the neuron called the axon terminal. They’re stored within thin-walled sacs called synaptic vesicles. Each vesicle can contain thousands of neurotransmitter molecules.

Detailed explanation-3: -Both groups released synaptic vesicles from isolated synaptosomes by osmotic shock. The content of acetylcholine in a vesicle was originally estimated to be 1000–2000 molecules. Subsequent work identified the vesicular localization of other neurotransmitters, such as amino acids, catecholamines, serotonin, and ATP.

Detailed explanation-4: -At rest, neurotransmitter-containing vesicles are stored at the terminal of the neuron in one of two places. A small number of vesicles are positioned along the pre-synaptic membrane in places called “active zones.” This is where neurotransmitter release occurs.

Detailed explanation-5: -The synaptic vesicles contain chemicals called neurotransmitters that transmit signals to postsynaptic neurons. Neurotransmitters are instinctual chemicals that allow nerve cells to connect with each other throughout the body.