ANATOMY

Detailed explanation-1: -A noncancerous (benign) tumor of the pituitary gland, located at the base of the brain, produces an excess amount of ACTH, which in turn stimulates the adrenal glands to make more cortisol. When this form of the syndrome develops, it’s called Cushing disease.

Detailed explanation-2: -Cushing’s syndrome is a hormonal disorder. It’s caused when you have high levels of the hormone cortisol over a long time. Cushing’s syndrome is fairly rare. It most often affects adults who are 20 to 50 years old. It is sometimes called hypercortisolism.

Detailed explanation-3: -Cushing disease is caused by a tumor or excess growth (hyperplasia) of the pituitary gland. The pituitary gland is located just below the base of the brain. A type of pituitary tumor called an adenoma is the most common cause. An adenoma is a benign tumor (not a cancer).

Detailed explanation-4: -Definition: Pituitary Cushing’s is a condition in which the pituitary gland (an organ of the endocrine system) secretes excess adrenocorticotropic hormone (ACTH). Causes, incidence, and risk factors: Cushing’s disease is a form of Cushing’s syndrome, in which excess cortisol (a stress hormone) is secreted.

Detailed explanation-5: -Too much ACTH in the body causes the adrenal glands to produce cortisol in high levels. Cushing disease can also occur with diffuse growth of the pituitary gland, also called pituitary hyperplasia.