ANATOMY

Detailed explanation-1: -Development of type 2 diabetes In general, type 2 diabetes develops when pancreatic cells fail to secrete sufficient amounts of insulin to meet the metabolic demand (Figure 1). An increased metabolic demand for insulin due to insulin resistance in several tissues usually precedes the development of hyperglycemia.

Detailed explanation-2: -A lot of blood sugar enters the bloodstream. The pancreas pumps out more insulin to get blood sugar into cells. Over time, cells stop responding to all that insulin-they’ve become insulin resistant. The pancreas keeps making more insulin to try to make cells respond.

Detailed explanation-3: -When you have type 2 diabetes, your fat, liver, and muscle cells do not respond correctly to insulin. This is called insulin resistance. As a result, blood sugar does not get into these cells to be stored for energy.

Detailed explanation-4: -The insulin receptor is a member of the ligand-activated receptor and tyrosine kinase family of transmembrane signaling proteins that collectively are fundamentally important regulators of cell differentiation, growth, and metabolism.