ANATOMY

Detailed explanation-1: -Gastrin is a peptide hormone primarily responsible for enhancing gastric mucosal growth, gastric motility, and secretion of hydrochloric acid (HCl) into the stomach. It is present in G cells of the gastric antrum and duodenum.

Detailed explanation-2: -The GI hormones that regulate gut mucosal growth positively or negatively include gastrin, CCK, secretin, somatostatin, ghrelin, bombesin, and gastrin-releasing peptide (GRP).

Detailed explanation-3: -Gastrin is a hormone that is produced by ‘G’ cells in the lining of the stomach and upper small intestine, and released into the blood circulation. During a meal, gastrin stimulates the stomach to release gastric acid (hydrochloric acid).

Detailed explanation-4: -The stomach is the primary site of gastrin production with some D-cells also populating the duodenum. Somatostatin and histamine are also produced in the stomach by enterochromaffin-like (ECL) cells, which is an enteroendocrine cell subtype.

Detailed explanation-5: -GASTROINTESTINAL (GI) HORMONES are chemical messengers that regulate intestinal and pancreatic function, including regulation of secretion, motility, absorption, digestion, and cell proliferation. These hormones are secreted by endocrine cells, which are widely distributed throughout the GI mucosa and pancreas.