ANATOMY

Detailed explanation-1: -Acromegaly is a hormonal disorder that develops when your pituitary gland produces too much growth hormone during adulthood. When you have too much growth hormone, your bones increase in size. In childhood, this leads to increased height and is called gigantism .

Detailed explanation-2: -Acromegaly is a disorder that occurs when your body makes too much growth hormone (GH). Produced mainly in the pituitary gland, GH controls the physical growth of the body. In adults, too much of this hormone causes bones, cartilage, body organs, and other tissues to increase in size.

Detailed explanation-3: -Acromegaly is a rare condition where the body produces too much growth hormone, causing body tissues and bones to grow more quickly. Over time, this leads to abnormally large hands and feet, and a wide range of other symptoms.

Detailed explanation-4: -Cushing’s syndrome (hypercortisolism): If your pituitary gland secretes too much adrenocorticotropic hormone (ACTH), your adrenal glands may release too much cortisol. Besides being a “stress hormone, ” cortisol manages the metabolism of proteins, fats and carbohydrates.

Detailed explanation-5: -GH excess is much rarer than GH deficiency in childhood and can be caused by pituitary adenomas, optic nerve gliomas (seen predominantly with NF1), McCune Albright syndrome, or Carney complex. Treatment is with surgery, somatostatin analogs, or GH receptor antagonists.