ANATOMY

Detailed explanation-1: -Addison’s disease, also called adrenal insufficiency, is an uncommon illness that occurs when the body doesn’t make enough of certain hormones. In Addison’s disease, the adrenal glands make too little cortisol and, often, too little of another hormone, aldosterone.

Detailed explanation-2: -Addison’s disease is usually the result of a problem with the immune system, which causes it to attack the outer layer of the adrenal gland (the adrenal cortex), disrupting the production of the steroid hormones aldosterone and cortisol.

Detailed explanation-3: -Addison’s disease is caused by under secretion of ACTH (Adrenocorticotropic hormone). It is produced by the pituitary glands. It stimulates the adrenal glands to produce the hormone cortisol. Cortisol stimulates gluconeogenesis and maintains blood pressure.

Detailed explanation-4: -So, the correct answer is ‘Addison’s disease’.

Detailed explanation-5: -Inadequate secretion of the adrenal glands, which is also called hyposecretion of adrenal glands, leads to Addison’s disease. Hyposecretion of the adrenal glands can be caused due to the destruction of the cells of the adrenal glands by the body’s own immune system.