ANATOMY

Detailed explanation-1: -What is the thyroid? Your thyroid is a small, butterfly-shaped gland located at the front of your neck under your skin. It’s a part of your endocrine system and controls many of your body’s important functions by producing and releasing (secreting) certain hormones.

Detailed explanation-2: -Thyroid: The thyroid (THY-royd) is in the front part of the lower neck. It’s shaped like a bow tie or butterfly. It makes the thyroid hormones thyroxine (thy-RAHK-sin) and triiodothyronine (try-eye-oh-doe-THY-ruh-neen). These hormones control the rate at which cells burn fuels from food to make energy.

Detailed explanation-3: -Adrenal gland. The adrenal glands make and release corticosteroid hormones and epinephrine that maintain blood pressure and regulate metabolism.

Detailed explanation-4: -Local activation of thyroxine (T4), to the active form, triiodothyronine (T3), by 5’-deiodinase type 2 (D2) is a key mechanism of TH regulation of metabolism. D2 is expressed in the hypothalamus, white fat, brown adipose tissue (BAT), and skeletal muscle and is required for adaptive thermogenesis.

Detailed explanation-5: -Metabolism: thyroid hormone increases the basal metabolic rate. It increases the gene expression of Na+/K+ ATPase in different tissues leading to increased oxygen consumption, respiration rate, and body temperature. Depending on the metabolic status, it can induce lipolysis or lipid synthesis.