GENERAL ANATOMY
ENDOCRINE SYSTEM
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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What activates adenylyl cyclase?
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epinephrine binding to it
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an activated G protein
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cAMP
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a protein kinase
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Explanation:
Detailed explanation-1: -Adenylyl cyclase can be activated directly by forskolin, a plant diterpene which has been useful in studies of enzyme regulation and purification. The substrate for adenylyl cyclase is a complex of Mg2+ and ATP.
Detailed explanation-2: -GTP-bound Gs alpha then binds to and stimulates adenylyl cyclase. Adenylyl cyclase is a membrane-bound enzyme that catalyzes the conversion of ATP to cAMP.
Detailed explanation-3: -When adenylyl cyclase is activated, it catalyses the conversion of ATP to cyclic AMP, which leads to an increase in intracellular levels of cyclic AMP.
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