ANATOMY

Detailed explanation-1: -Most hormones are controlled by negative feedback, in which the hormone feeds back to decrease its own production. This type of feedback brings things back to normal whenever they start to become too extreme. Positive feedback is much less common because it causes conditions to become increasingly extreme.

Detailed explanation-2: -Negative feedback keeps the concentration of a hormone within a relatively narrow range and maintains homeostasis. Very few endocrine hormones are regulated by positive feedback loops. Positive feedback causes the concentration of a hormone to become increasingly higher.

Detailed explanation-3: -Growth hormone secretion is also part of a negative feedback loop involving IGF-I. High blood levels of IGF-I lead to decreased secretion of growth hormone not only by directly suppressing the somatotroph, but by stimulating release of somatostatin from the hypothalamus.