ANATOMY

Detailed explanation-1: -The classical view of heterotrimeric G protein signaling places G proteins at the cytoplasmic surface of the cell’s plasma membrane where they are activated by an appropriate G protein-coupled receptor.

Detailed explanation-2: -G protein-coupled receptors (GPCRs) are integral membrane proteins that reside in the plasma membrane of eukaryotic cells. They are central to transmitting signals from the extracellular milieu to the inside of the cell.

Detailed explanation-3: -Heterotrimeric G-proteins mainly relay the information from G-protein-coupled receptors (GPCRs) on the plasma membrane to the inside of cells to regulate various biochemical functions. Depending on the targeted cell types, tissues and organs, these signals modulate diverse physiological functions.

Detailed explanation-4: -G protein-coupled receptors (GPCRs) are seven-transmembrane proteins that are located in the cell membrane, with their N-and C-termini located on the outer and inner surfaces, respectively. GPCRs mediate various cellular responses from the extracellular environment.