ANATOMY

Detailed explanation-1: -Groups of endocrine cells are found throughout the pancreas. They are called islets of Langerhans because they are scattered like small islands (“islets”) and were discovered by the pathologist Paul Langerhans. These groups of cells produce insulin, glucagon and other hormones.

Detailed explanation-2: -Understanding insulin, what insulin does, and how it affects the body, is important to your overall health. Tucked away behind the stomach is an organ called the pancreas, which produces insulin. Insulin production is regulated based on blood sugar levels and other hormones in the body.

Detailed explanation-3: -Insulin is a hormone produced in the pancreas by special cells, called beta cells. The pancreas is below and behind the stomach. Insulin is needed to move blood sugar (glucose) into cells. Inside the cells, glucose is stored and later used for energy.

Detailed explanation-4: -Insulin is secreted by the -cells of the pancreatic islets of Langerhans in response to elevation of the intracellular Ca2+ concentration ([Ca2+]i). This is produced by an influx of extracellular Ca2+ via voltage-dependent Ca2+ channels, whose activity, in turn, is regulated by the -cell membrane potential.

Detailed explanation-5: -The main hormones secreted by the endocrine gland in the pancreas are insulin and glucagon, which regulate the level of glucose in the blood, and somatostatin, which prevents the release of insulin and glucagon.