ANATOMY

Detailed explanation-1: -What is Hemophilia? Hemophilia is usually an inherited bleeding disorder in which the blood does not clot properly. This can lead to spontaneous bleeding as well as bleeding following injuries or surgery. Blood contains many proteins called clotting factors that can help to stop bleeding.

Detailed explanation-2: -Hemophilia is almost always a genetic disorder. Treatment includes regular replacement of the specific clotting factor that is reduced. Newer therapies that don’t contain clotting factors also are being used.

Detailed explanation-3: -Causes. Variants in the F8 gene cause hemophilia A, while variants in the F9 gene cause hemophilia B. The F8 gene provides instructions for making a protein called coagulation factor VIII. A related protein, coagulation factor IX, is produced from the F9 gene.

Detailed explanation-4: -The two main types of hemophilia are A and B, with a third, rarer form called hemophilia C. Each type is directly related to a specific factor; namely, hemophilia A is a factor VIII deficiency, hemophilia B is a factor IX deficiency, and hemophilia C is a factor XI deficiency.

Detailed explanation-5: -Haemophilia A (also known as Classic Haemophilia or Factor VIII deficiency) is the most well-known type of clotting disorder. A specific protein is missing from the blood so that injured blood vessels cannot heal in the usual way.