ANATOMY

Detailed explanation-1: -B cell development starts in the bone marrow (BM) and continues in the spleen to final maturation. Developmental progression is guided by sequential events leading to assembly, expression, and signaling of the B cell antigen receptor (BCR).

Detailed explanation-2: -Inside the bone marrow, blood stem cells divide and mature to make new blood cells. During this process, the cells become either lymphocytes (a kind of white blood cell) or other blood-forming cells. These other blood-forming cells mature into red blood cells, white blood cells (other than lymphocytes), or platelets.

Detailed explanation-3: -B cells mature in bone marrow and migrate to spleen & lymph nodes for interaction with Ag.

Detailed explanation-4: -B cells originate and mature in the red bone marrow, then after release they concentrate in the lymph nodes, respiratory tract, gastrointestinal tract, and spleen, ready for pathogenic invaders. Then upon encounter they will begin to produce plasma cells and memory cells.

Detailed explanation-5: -Additionally, B cells present antigens (they are also classified as professional antigen-presenting cells (APCs)) and secrete cytokines. In mammals, B cells mature in the bone marrow, which is at the core of most bones.