ANATOMY

Detailed explanation-1: -Instead, memory B cells are defined as long-lived and quiescent cells that are poised to quickly respond to antigen upon recall (2–5). Both memory B cells and antibody-secreting cells (ASCs) are the product of antigen activation and, most often, interaction with cognate T helper cells.

Detailed explanation-2: -In immunology, a memory B cell (MBC) is a type of B lymphocyte that forms part of the adaptive immune system. These cells develop within germinal centers of the secondary lymphoid organs. Memory B cells circulate in the blood stream in a quiescent state, sometimes for decades.

Detailed explanation-3: -The cellular basis for enduring antibody-mediated immunity is long-lived memory B cells and plasma cells (PCs). Both of these cell populations acquire longevity as a result of antigen-specific, CD40–dependent, cognate interactions with helper T cells within germinal centers (GCs).

Detailed explanation-4: -Lymphocytes are produced in response to the specific antigens on a pathogen. After the pathogen is removed some of the lymphocytes continue to remain in the immune system. These are called memory cells.

Detailed explanation-5: -Memory B cells, but not long-lived plasma cells, possess antigen specificities for viral escape mutants.