ANATOMY

Detailed explanation-1: -However, the T-cell receptor differs from the B-cell receptor in an important way: it does not recognize and bind antigen directly, but instead recognizes short peptide fragments of pathogen protein antigens, which are bound to MHC molecules on the surfaces of other cells.

Detailed explanation-2: - The receptors on the surface of B cells (BCRs) can bind to soluble antigens, while T cell receptors (TCRs) can only recognise an antigen when it is complexed with major histocompatibility complex (MHC) molecules on the surface of other cells. T cell receptor binding to MHC-antigen complex.

Detailed explanation-3: -During T cell-dependent activation, B cells absorb the antigen and then present pieces of the antigen on their surface via a major histocompatibility complex (MHC). Helper T cells can then recognize those antigens via the MHC and activate the B cells.

Detailed explanation-4: -B cells secrete antibodies to antigens in blood and other body fluids, but T cells cannot bind to free-floating antigens. Instead they bind to fragments of foreign proteins that are displayed on the surface of body cells.