ANATOMY

Detailed explanation-1: -Histamine (2-[3H-imidazol-4-yl]ethanamine) is an important chemical mediator that causes vasodilation and increased vascular permeability and may even contribute to anaphylactic reactions [1].

Detailed explanation-2: -Histamine, released by mast cells, induces permeability of the microvasculature that also induces angiogenesis. There is also evidence of mast cells enhancing angiogenesis in tumor growth (20).

Detailed explanation-3: -In allergic inflammation, antigen-stimulated mast cells release a range of mediators that can be subdivided into the preformed mediators, the synthesized lipid mediators, and the cytokines and chemokines. Histamine is a major preformed mediator released by mast cells and it strongly increases vascular permeability.

Detailed explanation-4: -Increase in vascular permeability is a conclusive response in the progress of inflammation. Under controlled conditions, leukocytes are known to migrate across the vascular barriers to the sites of inflammation without severe vascular rupture.

Detailed explanation-5: -One of the best-known chemical mediators released from cells during inflammation is histamine, which triggers vasodilation and increases vascular permeability.