ANATOMY

Detailed explanation-1: -This is called the primary or first viremia (virus in the blood). The Variola virus then invades more macrophages and the cells that cover the inside surfaces of the blood vessels (endothelial cells) in the liver, spleen, lymph nodes and bone marrow.

Detailed explanation-2: -Smallpox can be deadly if the virus attacks the circulatory system, bone marrow or respiratory system. As recently as the 1960s, around 12 million people caught this highly contagious disease and approximately two million people died every year.

Detailed explanation-3: -Smallpox lesions, which are almost always preceded by illness with a high fever, are more numerous on the face, arms and legs, and the rash or pocks are usually present on the palms and soles.

Detailed explanation-4: -The rash develops into sores that break open. Typically within a day, the rash spreads to the face and then to the arms and legs, followed by the hands, feet, and the rest of the body. As the rash develops, the fever may go down, causing infected people to feel like they’re getting better.

Detailed explanation-5: -Despite their best efforts, smallpox was still widespread in 1966, causing regular outbreaks across South America, Africa, and Asia. The Intensified Eradication Program began in 1967 with a promise of renewed efforts.