ANATOMY

Detailed explanation-1: -HIV targets CD4 + T cells by binding to the CD4 molecule on the cell surface, as well as a chemokine coreceptor – usually CCR5 or CXCR4.

Detailed explanation-2: -Human Immunodeficiency Virus (HIV) specifically attacks Helper T cells. Without an adequate supply of Helper T cells, the immune system cannot signal B cells to produce antibodies or Cytotoxic T cells to kill infected cells.

Detailed explanation-3: -CD4 on CD8+ T cells directly enhances effector function and is a target for HIV infection.

Detailed explanation-4: -RESULT. We show that active HIV-1 replication induces in vivo bystander activation of CD4+ T cells which are specific for persistent herpes virus antigens, whereas no activation was observed for CD4+ T cells with specificity for non-persistent antigens.

Detailed explanation-5: -HIV is a unique human RNA virus, capable of infecting cells of the immune system. Specifically, HIV targets T helper cells (CD4 cells), leading to the eventual death of the cell.