ANATOMY

Detailed explanation-1: -The complement system, also known as complement cascade, is a part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen’s cell membrane.

Detailed explanation-2: -Receptors for complement components have been previously described in various cell types including monocytes. The complement receptor 3 (CR3), comprising CD11b, and CD18, is expressed by all monocytes and critical for facilitating phagocytosis of complement-opsonized cells or pathogens (20).

Detailed explanation-3: -The most important action of complement is to facilitate the uptake and destruction of pathogens by phagocytic cells. This occurs by the specific recognition of bound complement components by complement receptors (CRs) on phagocytes.

Detailed explanation-4: -First, complement factors directly promote vascular cell dysfunction through their specific receptors in effector cells. However, complement activation mediates immune cell recruitment and induces inflammatory factor production in these cells.

Detailed explanation-5: -What is the complement system? The complement system is part of your body’s immune system that cleans up damaged cells, helps your body heal after an injury or an infection and destroys microscopic organisms like bacteria that make you sick. Your complement system is the front line of defense for your immune system.