ANATOMY

Detailed explanation-1: -Injured tissue mast cells release histamine, causing the surrounding blood vessels to dilate and increase in permeability.

Detailed explanation-2: -The message is, “Release histamines, ” which are stored in the mast cells. When they leave the mast cells, histamines boost blood flow in the area of your body the allergen affected. This causes inflammation, which lets other chemicals from your immune system step in to do repair work.

Detailed explanation-3: -Mast cells respond to IL-33 released during cell injury by initiating a pro-inflammatory response. During cell injury, for instance induced by mechanical trauma, structural cell types such as epithelial cells release IL-33.

Detailed explanation-4: -Acute phase response is generated during inflammation. Histamine is a vasoactive amine that plays an important role in the early acute inflammatory response. Histamine is stored in the granules of mast cells, basophils, platelets.

Detailed explanation-5: -When mast cells detect a substance that triggers an allergic reaction (an allergen), they release histamine and other chemicals into the bloodstream. Histamine makes the blood vessels expand and the surrounding skin itchy and swollen. It can also create a build-up of mucus in the airways, which become narrower.