ANATOMY

Detailed explanation-1: -While an infection of the variola minor virus would lead to death with a probability of less than one percent, the case fatality rate of the variola major virus has been estimated to be around 30 percent.

Detailed explanation-2: -Variolation used a lancet or needle to introduce pulverized dried smallpox scabs or pustule fluid into the skin of an individual. This resulted in a milder form of the disease with a much lower fatality rate (2–3%), compared to natural smallpox infection.

Detailed explanation-3: -After variolation, people usually developed the symptoms associated with smallpox, such as fever and a rash. However, fewer people died from variolation than if they had acquired smallpox naturally.

Detailed explanation-4: -Dried smallpox scabs were blown into the nose of an individual who then contracted a mild form of the disease. Upon recovery, the individual was immune to smallpox. Between 1% to 2% of those variolated died as compared to 30% who died when they contracted the disease naturally.

Detailed explanation-5: -Risks of Variolation Possible risks from the procedure include: Developing a severe smallpox infection. People with compromised immune systems or who received too much of the virus were at risk of developing a full-fledged smallpox infection. Spreading the disease to others.