GENERAL ANATOMY
IMMUNE SYSTEM
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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What specific part of the antigen receptor is responsible for the variation?
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The variable regions of light chain and heavy chain
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The constant region
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The variable region on the light chain only
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The macrophages
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Explanation:
Detailed explanation-1: -Hypervariable regions form the antigen binding site and are found on both light and heavy chains. They also contribute to the specificity of each antibody.
Detailed explanation-2: -The “variable” region includes 110-130 amino acids of the light and heavy chains, and is responsible for binding to antigen. This part of the antibody shows variations in amino acids when the specificity of the antibody for antigen is changed.
Detailed explanation-3: -Epitopes or antigenic determinants are regions of proteins that can trigger a cellular immune response mediated by T or B cells.
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