ANATOMY

Detailed explanation-1: -The thymus is divided into two main regions, a peripheral cortex and a central medulla (see Fig. 7.7). Most T-cell development takes place in the cortex; only mature single-positive thymocytes are seen in the medulla. At the outer edge of the cortex, in the subcapsular region of the thymus (Fig.

Detailed explanation-2: -T cells migrate from the bone marrow to the thymus, a small gland located in the neck. Here, they mature and differentiate into different types of T cells, such as CD8+ T cells and CD4+ T cells.

Detailed explanation-3: -The thymus supports the differentiation of multiple distinct T cell subsets that play unique roles in the immune system. CD4 and CD8 / T cells, / T cells, NKT cells, Treg, and IEL all develop in and must leave the thymus to provide their functions elsewhere in the body.