ANATOMY

Detailed explanation-1: -Abstract. In vertebrate striated muscle, troponin-tropomyosin is responsible, in part, not only for transducing the effect of calcium on contractile protein activation, but also for inhibiting actin and myosin interaction when calcium is absent.

Detailed explanation-2: -Thin-filament regulation of actomyosin interaction is modulated by two actin-binding regulatory proteins: tropomyosin (TM) and caldesmon (CaD).

Detailed explanation-3: -Tropomyosin and troponin prevent myosin from binding to actin while the muscle is in a resting state.

Detailed explanation-4: -Regulatory Proteins Tropomyosin blocks myosin binding sites on actin molecules, preventing cross-bridge formation and preventing contraction in a muscle without nervous input. Troponin binds to tropomyosin and helps to position it on the actin molecule; it also binds calcium ions.

Detailed explanation-5: -Regulatory Proteins Troponin binds to tropomyosin and helps to position it on the actin molecule; it also binds calcium ions.