ANATOMY

Detailed explanation-1: -The absolute refractory period is a period of time after the initiation of one action potential when it is impossible to initiate a second action potential no matter how much the cell is depolarized.

Detailed explanation-2: -By definition, the refractory period is a period of time during which a cell is incapable of repeating an action potential. In terms of action potentials, it refers to the amount of time it takes for an excitable membrane to be ready to respond to a second stimulus once it returns to a resting state.

Detailed explanation-3: -After an action potential starts, the membrane is typically unresponsive to new stimuli until the resting potential is re-established. This time span is called the refractory period. absolute refractory period. It extends from the start of the action potential until the K+ channels begin to close.

Detailed explanation-4: -During the absolute refractory period the neuron cannot fire another action potential because all of the sodium gates are inactivated. The neuron then begins to repolarize (become more negative) by opening voltage-gated potassium channels allowing positively charged potassium to flood out of the cell.

Detailed explanation-5: -In its wake, the action potential leaves the Na+ channels inactivated and K+ channels activated for a brief time. These transitory changes make it harder for the axon to produce subsequent action potentials during this interval, which is called the refractory period.