ANATOMY

Detailed explanation-1: -H-band is the zone of the thick filaments that has no actin. Within the H-zone is a thin M-line (from the German “mittel” meaning middle), appears in the middle of the sarcomere formed of cross-connecting elements of the cytoskeleton.

Detailed explanation-2: -Each sarcomere has a central A band made of thick myosin filaments and two half I bands made of thin actin filaments on either side of the thick filaments leaving the central part of the thick filaments. This central part of thick filament, not overlapped by thin filament is called H zone.

Detailed explanation-3: -The H-zone consists of myosin only, the I-band consists of actin only and the A-band contains both actin and myosin. The M-line holds together the thick myosin filaments. The Z-line differentiates between each sarcomere.

Detailed explanation-4: -The myosin and actin filaments overlap in peripheral regions of the A band, whereas a middle region (called the H zone) contains only myosin. The actin filaments are attached at their plus ends to the Z disc, which includes the crosslinking protein -actinin.

Detailed explanation-5: -Hence H-zone in skeletal muscle fibre is due to the Central gap between actin filaments extending through myosin filaments in the A-band.