ANATOMY

Detailed explanation-1: -Normally, these nerve cells, or neurons, produce an important brain chemical known as dopamine. When the neurons die or become impaired, they produce less dopamine, which causes the movement problems associated with the disease.

Detailed explanation-2: -These nerve cells die or become impaired, losing the ability to produce an important chemical called dopamine. Studies have shown that symptoms of Parkinson’s develop in patients with an 80 percent or greater loss of dopamine-producing cells in the substantia nigra.

Detailed explanation-3: -Without dopamine, the brain can’t properly send electrical signals to your body. Signs and symptoms of the dopamine drop will begin to appear. These include tremor, muscle stiffness, and loss of coordination. Ultimately, a Parkinson’s disease diagnosis is likely.

Detailed explanation-4: -Low levels of dopamine may disrupt the nigrostriatal pathway and cause abnormal nerve firing patterns, which can result in movement problems. Evidence suggests that most people with PD lose 60–80% or more of dopamine-producing cells in the substantia nigra by the time they present symptoms.

Detailed explanation-5: -Scientists believe a lack of dopamine causes Parkinson’s disease. That deficit, they say, comes from a disorder of nerve cells in the part of the brain that produces the chemical. However, dopamine isn’t the only neurotransmitter affected in Parkinson’s disease.