ANATOMY

Detailed explanation-1: -Congenital insensitivity to pain is a condition that inhibits the ability to perceive physical pain. From birth, affected individuals never feel pain in any part of their body when injured.

Detailed explanation-2: -For people with this disorder, cognition and sensation are otherwise normal; for instance, patients can still feel discriminative touch (though not always temperature), and there are generally no detectable physical abnormalities.

Detailed explanation-3: -Disease at a Glance Congenital insensitivity to pain is caused by genetic changes in the SCN9A gene and, in rare cases, is caused by genetic changes in the PMRD12 gene. It is inherited in an autosomal recessive pattern.

Detailed explanation-4: -Your doctor will diagnose congenital insensitivity to pain by testing your baby’s pain response to pricking with something that typically causes pain but doesn’t cause damage or scarring, like a needle. To confirm the results of this test, your doctor may recommend genetic testing.