ANATOMY

Detailed explanation-1: -Both modeling and remodeling involve the cells that form bone called osteoblasts and the cells that break down bone, called osteoclasts (Figure 2-3).

Detailed explanation-2: -Osteoclasts are the cells that degrade bone to initiate normal bone remodeling and mediate bone loss in pathologic conditions by increasing their resorptive activity. They are derived from precursors in the myeloid/monocyte lineage that circulate in the blood after their formation in the bone marrow.

Detailed explanation-3: -Osteoblasts (bottom image on the right) are produced by bone cells and are the bone builders. They are responsible for the synthesis and mineralization of bone during both the initial bone formation process and later bone remodeling process.

Detailed explanation-4: -Under normal physiological conditions osteoblasts are responsible for the formation of new bone in the developing skeleton and during the process of bone remodelling.

Detailed explanation-5: -Osteoclasts are large multinucleated cells from hematopoietic origin and are responsible for bone resorption. A balance between osteoclastic bone resorption and osteoblastic bone formation is critical to maintain bone homeostasis.