ANATOMY

Detailed explanation-1: -Osteoclasts also participate in the long-term maintenance of blood calcium homeostasis. During bone resorption, the osteoclasts resorb the bone surface forming depressions known as Howship’s lacunae.

Detailed explanation-2: -Osteoclasts are the cells that degrade bone to initiate normal bone remodeling and mediate bone loss in pathologic conditions by increasing their resorptive activity. They are derived from precursors in the myeloid/monocyte lineage that circulate in the blood after their formation in the bone marrow.

Detailed explanation-3: -Osteoclasts resorb bone through the production of proteolytic enzymes and secretion of hydrogen ions into the localized microenvironment under the ruffled border. This extracellular lysosome that is formed beneath the ruffled border results in degradation of collagen and calcified matrix.

Detailed explanation-4: -Osteoclasts dissolve bone mineral by massive acid secretion and secrete specialized proteinases that degrade the organic matrix, mainly type I collagen, in this acidic milieu.

Detailed explanation-5: -Osteoblasts, osteocytes and osteoclasts are the three cell types involved in the development, growth and remodeling of bones. Osteoblasts are bone-forming cells, osteocytes are mature bone cells and osteoclasts break down and reabsorb bone.