ANATOMY

Detailed explanation-1: -Between the rings of matrix, the bone cells (osteocytes) are located in spaces called lacunae. Small channels (canaliculi) radiate from the lacunae to the osteonic (haversian) canal to provide passageways through the hard matrix.

Detailed explanation-2: -Osteocytes, the cells residing within the bone matrix, make up between 90% to 95% of the cellular component in skeletally mature adult bone tissue.

Detailed explanation-3: -Osteocytes are the most abundant cell type in mature bone and are contained within small holes (lacunae) in the bone tissue [2].

Detailed explanation-4: -Osteoclasts occupy small depressions on the bone’s surface, called Howship lacunae; the lacunae are thought to be caused by erosion of the bone by the osteoclasts’ enzymes. Osteoclasts are formed by the fusion of many cells derived from circulating monocytes in the blood. These in turn are derived from the bone marrow.

Detailed explanation-5: -Animal Models of Bone Disease-B Osteocytes are most often described as terminally differentiated osteoblasts that reside in small pockets termed lacunae, located deep within mineralized bone.