ANATOMY

Detailed explanation-1: -Bone-forming cells, traditionally termed osteoblasts, produce, assemble, and control the mineralization of the type I collagen-enriched bone matrix while participating in the regulation of other cell processes, such as osteoclastogenesis, and metabolic activities, such as phosphate homeostasis.

Detailed explanation-2: -Five steps can summarize intramembranous ossification: Mesenchymal cells differentiate into osteoblasts and group into ossification centers. Osteoblasts become entrapped by the osteoid they secrete, transforming them to osteocytes. Trabecular bone and periosteum form.

Detailed explanation-3: -Osteoclasts are the cells that degrade bone to initiate normal bone remodeling and mediate bone loss in pathologic conditions by increasing their resorptive activity. They are derived from precursors in the myeloid/monocyte lineage that circulate in the blood after their formation in the bone marrow.

Detailed explanation-4: -Osteoblasts. Osteoblasts are cuboidal cells that are located along the bone surface comprising 4–6% of the total resident bone cells and are largely known for their bone forming function [22].