ANATOMY

Detailed explanation-1: -Calcium is the major component of the bone, where it is present at more than 99% as calcium-phosphate complexes, and provides the skeleton strength and structure, making the bone a metabolic reservoir to maintain the intra-and extra-cellular calcium pool.

Detailed explanation-2: -Bone remodeling serves to adjust bone architecture to meet changing mechanical needs and it helps to repair microdamages in bone matrix preventing the accumulation of old bone. It also plays an important role in maintaining plasma calcium homeostasis. The regulation of bone remodeling is both systemic and local.

Detailed explanation-3: -Parathyroid hormone (PTH): The main role of this hormone is to keep blood calcium levels stable. If calcium levels fall too low, the parathyroid glands release PTH. This causes the bones to breakdown so that calcium can be released from the bones into the bloodstream.

Detailed explanation-4: -Abstract. Bone remodeling is thought to be regulated by many factors including nutritional status, humoral factors, and biomechanical stress.