ANATOMY

Detailed explanation-1: -This process involves the replacement of hyaline cartilage with bone. It begins when mesoderm-derived mesenchymal cells differentiate into chondrocytes. Chondrocytes proliferate rapidly and secrete an extracellular matrix to form the cartilage model for bone.

Detailed explanation-2: -Endochondral ossification involves the replacement of hyaline cartilage with bony tissue. Most of the bones of the skeleton are formed in this manner. These bones are called endochondral bones. In this process, the future bones are first formed as hyaline cartilage models.

Detailed explanation-3: -Endochondral ossification is the process by which bone tissue is formed in early fetal development. It begins when mesenchymal stem cells (MSC’s) start to produce a cartilage template of long bones, such as the femur and the tibia, upon which bone morphogenesis occurs (Ortega et al., 2004).

Detailed explanation-4: -The skeletal components of the vertebral column, the pelvis, and the limbs are first formed of cartilage and later become bone. The replacement of chondrocytes by bone cells is dependent on the mineralization of the extracellular matrix.

Detailed explanation-5: -Endochondral ossification occurs at two distinct sites in the vertebrate long bone – the primary (diaphyseal) and the secondary (epiphyseal) sites of ossification. Bone development initiates at the primary site.