ANATOMY

Detailed explanation-1: -Osteocytes are the engineers and experienced builders. They make up about 90% of bone cells and are found in the bone matrix. They communicate with other cells and regulate osteoblasts’ and osteoclasts’ work to shape the bone. Thus, osteocytes are responsible for new bone growth and repair.

Detailed explanation-2: -Osteoblasts result in the formation of new layers of bone by producing a matrix that covers the older bone surface. The bone matrix then surrounds the osteoblast cells, which are converted to mature bone cells known as osteocytes. Osteocytes produce the components essential for maintaining the bone matrix.

Detailed explanation-3: -The primary role of osteoblasts is to lay down new bone during skeletal development and remodelling. Throughout this process osteoblasts directly interact with other cell types within bone, including osteocytes and haematopoietic stem cells.

Detailed explanation-4: -During bone remodeling osteoclasts, derived from hematopoietic stem cells, resorb old, or damaged bone. Subsequently, osteoblasts, derived from mesenchymal stem cells, are recruited to the damaged area in order to replace bone removed by osteoclasts.

Detailed explanation-5: -Bone repair is the natural process in which a bone repairs itself following a bone fracture. This process may take several weeks. In the process, periosteum produces cells that develop into osteoblasts, and the osteoblasts form new bone matrix to heal the fracture.