ANATOMY

Detailed explanation-1: -This process involves the replacement of hyaline cartilage with bone. It begins when mesoderm-derived mesenchymal cells differentiate into chondrocytes. Chondrocytes proliferate rapidly and secrete an extracellular matrix to form the cartilage model for bone.

Detailed explanation-2: -The process by which a cartilage intermediate is formed and replaced by bone cells is called endochondral ossification.

Detailed explanation-3: -There are two processes resulting in the formation of normal, healthy bone tissue: Intramembranous ossification is the direct laying down of bone into the primitive connective tissue (mesenchyme), while endochondral ossification involves cartilage as a precursor.

Detailed explanation-4: -Endochondral ossification is the process by which growing cartilage is systematically replaced by bone to form the growing skeleton. This process occurs at three main sites: the physis, the epiphysis, and the cuboidal bones of the carpus and tarsus.