ANATOMY

Detailed explanation-1: -The purpose of bone remodeling is to regulate calcium homeostasis, repair micro-damage to bones from everyday stress, and to shape the skeleton during growth.

Detailed explanation-2: -Bone remodeling serves to adjust bone architecture to meet changing mechanical needs and it helps to repair microdamages in bone matrix preventing the accumulation of old bone. It also plays an important role in maintaining plasma calcium homeostasis. The regulation of bone remodeling is both systemic and local.

Detailed explanation-3: -There are four stages in the repair of a broken bone: 1) the formation of hematoma at the break, 2) the formation of a fibrocartilaginous callus, 3) the formation of a bony callus, and 4) remodeling and addition of compact bone.

Detailed explanation-4: -The growth hormone/IGF-1 system stimulates both the bone-resorbing and bone-forming cells, but the dominant effect is on bone formation, thus resulting in an increase in bone mass. Thyroid hormones increase the energy production of all body cells, including bone cells.