ANATOMY

Detailed explanation-1: -Osteoclasts are the cells that degrade (resorb) bone during normal bone remodeling and in pathologic states in which bone resorption is increased.

Detailed explanation-2: -Osteoblasts are bone-forming cells, osteocytes are mature bone cells and osteoclasts break down and reabsorb bone.

Detailed explanation-3: -OSTEOCLASTS are large cells that dissolve the bone. They come from the bone marrow and are related to white blood cells. They are formed from two or more cells that fuse together, so the osteoclasts usually have more than one nucleus. They are found on the surface of the bone mineral next to the dissolving bone.

Detailed explanation-4: -Osteocytes. Osteocytes are the most abundant cell type in mature bone. These cell types are situated within the bone matrix and occupy microscopic spaces called lacuna. They play a role in bone remodeling by transmitting signals to nearby osteocytes regarding bone stress (tendons pulling on the bone).

Detailed explanation-5: -Many types of cells and factors are involved in the process of bone remodeling. Osteoblast and osteoclast are the two main cells participating in those progresses (Matsuo and Irie, 2008). Osteoclasts are responsible for aged bone resorption and osteoblasts are responsible for new bone formation (Matsuoka et al., 2014).