ANATOMY

Detailed explanation-1: -Endochondral ossification involves the replacement of hyaline cartilage with bony tissue. Most of the bones of the skeleton are formed in this manner.

Detailed explanation-2: -Endochondral ossification is the process of bone development from hyaline cartilage. All of the bones of the body, except for the flat bones of the skull, mandible, and clavicles, are formed through endochondral ossification. In long bones, chondrocytes form a template of the hyaline cartilage diaphysis.

Detailed explanation-3: -Endochondral Ossification This process involves the replacement of hyaline cartilage with bone. It begins when mesoderm-derived mesenchymal cells differentiate into chondrocytes. Chondrocytes proliferate rapidly and secrete an extracellular matrix to form the cartilage model for bone.

Detailed explanation-4: -Ossification begins as mesenchymal cells form a template of the future bone. They then differentiate into osteoblasts at the ossification center. Osteoblasts secrete the extracellular matrix and deposit calcium, which hardens the matrix.

Detailed explanation-5: -Cartilage is formed from the mesoderm germ layer by the process known as chondrogenesis. [5] Mesenchyme differentiates into chondroblasts, which are the cells that secrete the major components of the extracellular matrix-the most important of these components for cartilage formation being aggrecan and type II collagen.