ANATOMY

Detailed explanation-1: -Endochondral ossification begins with mesenchymal tissue transforming into a cartilage intermediate, which is later replaced by bone and forms the remainder of the axial skeleton and the long bones.

Detailed explanation-2: -Prior to osteogenesis, or the creation of bone tissue, the embryonic skeleton is made of hyaline cartilage.

Detailed explanation-3: -Hyaline cartilage is the most widespread and is the type that makes up the embryonic skeleton. It persists in human adults at the ends of bones in free-moving joints as articular cartilage, at the ends of the ribs, and in the nose, larynx, trachea, and bronchi.

Detailed explanation-4: -Long bones have a thick outside layer of compact bone and an inner medullary cavity containing bone marrow. The ends of a long bone contain spongy bone and an epiphyseal line. The epiphyseal line is a remnant of an area that contained hyaline cartilage that grew during childhood to lengthen the bone.

Detailed explanation-5: -Cartilage is formed from the mesoderm germ layer by the process known as chondrogenesis. Mesenchyme differentiates into chondroblasts which are the cells that secrete the major components of the extracellular matrix. The most important of these components for cartilage formation being aggrecan and type II collagen.