ANATOMY

Detailed explanation-1: -Osteoclasts are involved in bone resorption that contributes to bone remodelling in response to growth or changing mechanical stresses upon the skeleton. Osteoclasts also participate in the long-term maintenance of blood calcium homeostasis.

Detailed explanation-2: -Bone tissue is continuously remodeled through the concerted actions of bone cells, which include bone resorption by osteoclasts and bone formation by osteoblasts, whereas osteocytes act as mechanosensors and orchestrators of the bone remodeling process.

Detailed explanation-3: -Osteoclasts are responsible for resorbing, or breaking down, bone matrix. A balance between bone production and bone resorption is necessary for remodeling and renewing your skeleton. Osteocytes are mature osteoblasts that have become trapped within the very bone matrix they produced.

Detailed explanation-4: -Osteoclasts are responsible for aged bone resorption and osteoblasts are responsible for new bone formation (Matsuoka et al., 2014). The resorption and formation is in stable at physiological conditions. However, when the balance is disturbed, bone architecture or function will be abnormal.